Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary intraocular posttransplantation lymphoproliferative disorder

W L Clark1, I U Scott, T G Murray

  • 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Fla., USA.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|December 31, 1998
PubMed
Summary

We present a rare case of posttransplantation lymphoproliferative disorder (PTLD) in a young child, presenting as an isolated eye tumor. This finding highlights PTLD

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intravitreal and subconjunctival melphalan for retinoblastoma in transgenic mice.

Journal of ophthalmology·2014
Same author

Association of outer retinal layer morphology with visual acuity in patients with retinal vein occlusion: SCORE Study Report 13.

Eye (London, England)·2012
Same author

Effect of lyophilization on the in vitro biological activity of bevacizumab.

Eye (London, England)·2010
Same author

Effect of cataract on a scotopic sensitivity screening test for glaucoma.

Journal of glaucoma·2009
Same author

Lack of effect of SU1498, an inhibitor of vascular endothelial growth factor receptor-2, in a transgenic murine model of retinoblastoma.

The open ophthalmology journal·2009
Same author

Intraoperative bleeding during vitrectomy for diabetic tractional retinal detachment with versus without preoperative intravitreal bevacizumab (IBeTra study).

The British journal of ophthalmology·2009

Area of Science:

  • Pediatric Oncology
  • Transplantation Immunology
  • Ophthalmic Pathology

Background:

  • Posttransplantation lymphoproliferative disorder (PTLD) is a serious complication following organ transplantation.
  • PTLD typically involves lymphoid proliferation, often associated with Epstein-Barr virus (EBV) reactivation.
  • Ocular manifestations of PTLD are uncommon, with isolated iris involvement being exceedingly rare.

Observation:

  • A 2-year-old boy, who received a liver transplant for biliary atresia at 4 months old, presented with a progressively enlarging iris nodule over two months.
  • The patient had no other signs or symptoms suggestive of systemic PTLD at the time of presentation.
  • Clinical examination revealed a unilateral, isolated iris mass.

Findings:

  • Histopathologic examination of the iris lesion confirmed a diagnosis of PTLD.

Related Experiment Videos

  • The tumor comprised a mixed population of lymphoid cells, consistent with PTLD.
  • This case represents the youngest reported patient with PTLD manifesting solely within the eye.

    • Implications:

    • This case underscores the importance of considering PTLD in the differential diagnosis of pediatric ocular tumors, especially in transplant recipients.
    • Early recognition and diagnosis of ocular PTLD are crucial for timely management and potentially preventing systemic dissemination.
    • Further research into the specific mechanisms and risk factors for isolated ocular PTLD in pediatric transplant patients is warranted.