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07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Kaposi's sarcoma in renal transplant recipients
F A Shaheen1, M H al-Sulaiman, K S Ramprasad
1Saudi Center for Organ Transplantation, Riyadh, Saudi Arabia.
Annals of Transplantation
|January 1, 1997
Summary
Cancer transmission from organ donors is a significant risk, with 43% of recipients receiving organs from donors with malignancies developing transmitted cancers. Implementing rigorous donor screening and organ examination is crucial to prevent cancer transmission in organ transplantation.
Area of Science:
- Transplant medicine
- Oncology
- Public health
Background:
- Organ transplantation is a life-saving procedure, but carries the risk of transmitting diseases from donor to recipient.
- Malignancies in organ donors present a unique challenge due to the potential for cancer transmission.
Purpose of the Study:
- To quantify the incidence of cancer transmission from organ donors with malignancies to recipients.
- To identify the patterns of cancer spread in recipients of organs from donors with malignancies.
- To highlight the importance of preventive measures in minimizing cancer transmission during organ procurement.
Main Methods:
- Retrospective analysis of organ recipients whose donors had a history of malignancies.
- Documentation of transmitted cancers, including those involving allografts, adjacent structures, and distant metastases.
- Review of instances where neoplasms were removed from allografts prior to transplantation.
Main Results:
- Out of 270 organ recipients from donors with malignancies, 117 (43%) showed evidence of transmitted cancers.
- Neoplasms involved the allograft in 45 recipients, invaded adjacent structures in 6, and caused distant metastases in 66.
- In 9 cases, cancers involving renal allografts were detected and removed before transplantation.
Conclusions:
- Cancer transmission from donors with malignancies is a substantial concern in organ transplantation.
- Comprehensive donor screening, meticulous organ examination, biopsy of suspicious lesions, and donor autopsy are essential precautions.
- These measures are critical for reducing the risk of occult cancer transmission and improving patient outcomes.
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