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Related Experiment Videos

Gonadotropins do not induce antiphospholipid antibodies

R D Franklin1, R A Bronson, W H Kutteh

  • 1Department of Obstetrics and Gynecology, University of Tennessee, Memphis, USA.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|December 31, 1998
PubMed
Summary

Gonadotropin stimulation in assisted reproduction does not appear to cause antiphospholipid antibodies (APAs). The higher incidence of APAs in women undergoing fertility treatments is not explained by cycle-induced events.

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Area of Science:

  • Reproductive Endocrinology
  • Immunology
  • Assisted Reproductive Technology

Background:

  • Women undergoing assisted reproduction often exhibit a higher incidence of antiphospholipid antibodies (APAs).
  • Superovulation with gonadotropins is a key component of assisted reproduction protocols.
  • The potential link between gonadotropin stimulation and APA induction requires investigation.

Purpose of the Study:

  • To investigate whether gonadotropin-induced superovulation in assisted reproduction leads to an increased incidence of antiphospholipid antibodies (APAs).
  • To determine if women undergoing assisted reproduction are predisposed to abnormal immune responses, specifically APA development, due to ovarian stimulation.

Main Methods:

  • Prospective study comparing three groups of women: first-time assisted reproduction patients undergoing gonadotropin stimulation (group 1), patients with prior gonadotropin stimulation (group 2), and normal fertile controls (group 3).

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  • Serum samples were collected before, during, and after the stimulation cycle for group 1.
  • Enzyme-linked immunosorbent assay (ELISA) was used to detect antiphospholipid antibodies.

    • Main Results:

    • Antiphospholipid antibodies (APAs) were detected in 20% of women in group 1 and 24% in group 2.
    • APA incidence in both treatment groups was significantly higher than in the normal fertile control group (2%).
    • APA positivity in group 1 persisted throughout the treatment cycle, and there was no significant difference in APA rates between group 1 and group 2.

    Conclusions:

    • Gonadotropin administration and the subsequent ovarian response do not appear to induce antiphospholipid antibodies (APAs).
    • The elevated prevalence of APAs observed in women undergoing assisted reproduction is not attributable to events within the stimulation cycle.
    • Further research is needed to elucidate the underlying causes for the higher APA incidence in this population.