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Methotrexate-induced hepatic necrosis requiring liver transplantation in a patient with rheumatoid arthritis
N S Hakim1, B Kobienia, E Benedetti
1Department of Surgery, University of Minnesota, Minneapolis, USA.
Abstract:
MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis. A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis. He was successfully transplanted.
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