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Antibiotic-associated haemorrhagic colitis
A M Miller1, M L Bassett, J E Dahlstrom
1Gastroenterology Unit, The Canberra Hospital, Australia.
Journal of Gastroenterology and Hepatology
|December 31, 1998
Summary
Antibiotic-associated haemorrhagic colitis, a rare cause of bloody diarrhea linked to penicillin antibiotics, typically resolves after drug cessation. This review highlights its occurrence and unknown pathogenesis.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Antibiotic-associated haemorrhagic colitis is an uncommon gastrointestinal condition.
- It is associated with the use of penicillin and related antibiotics.
Observation:
- Symptoms include abdominal pain and bloody diarrhea within one week of antibiotic initiation.
- The condition appears more prevalent in patients of Oriental ethnicity.
- Two cases are presented, one treated for Helicobacter pylori infection.
Findings:
- The pathogenesis of antibiotic-associated haemorrhagic colitis remains unknown.
- Histological findings and pathogenesis are reviewed in the literature.
Implications:
- Early recognition and discontinuation of the offending antibiotic are crucial for resolution.
- Further research into the pathogenesis may elucidate preventative strategies.