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Recurrence in meningeal hemangiopericytomas
M Hara1, M Aoyagi, G Nagashima
1Department of Neurosurgery, School of Medicine, Tokyo Medical and Dental University, Japan.
Surgical Neurology
|December 31, 1998
Summary
Meningeal hemangiopericytomas can be aggressive. P53 protein accumulation and high proliferation indicate malignant progression, aiding in prognosis for these rare tumors.
Area of Science:
- Neuro-oncology
- Surgical Pathology
Background:
- Meningeal hemangiopericytomas exhibit aggressive behavior, characterized by high recurrence rates and metastatic potential, distinguishing them from typical meningiomas.
- The prognostic significance of histologic features in meningeal hemangiopericytomas remains debated.
Observation:
- Two cases of recurrent meningeal hemangiopericytomas are presented, illustrating varied clinical trajectories.
- Case 1 showed tumor dissemination and extracranial metastasis post-treatment, despite initial local control.
- Case 2 experienced a favorable outcome following tumor removal.
Findings:
- Elevated Ki-67 proliferative index and p53 protein accumulation correlated with tumor recurrence and aggressive behavior in Case 1.
- In contrast, Case 2 demonstrated stable Ki-67 levels and negative p53 staining in both primary and recurrent tumors.
Implications:
- P53 protein accumulation, alongside a high proliferative index (Ki-67), serves as a valuable biomarker for predicting malignant progression in meningeal hemangiopericytomas.
- These findings can assist clinicians in assessing prognosis and guiding treatment strategies for patients with these challenging tumors.