Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anaplastic pleomorphic xanthoastrocytoma

R A Prayson1, H H Morris

  • 1Department of Anatomic Pathology, Cleveland (Ohio) Clinic Foundation, 44195, USA.

Archives of Pathology & Laboratory Medicine
|December 31, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hamartia in hippocampal sclerosis-associated mesial temporal lobe epilepsy.

Annals of diagnostic pathology·2017
Same author

Re-review of MRI with post-processing in nonlesional patients in whom epilepsy surgery has failed.

Journal of neurology·2016
Same author

Effects of dual pathology on cognitive outcome following left anterior temporal lobectomy for treatment of epilepsy.

Epilepsy & behavior : E&B·2013
Same author

Necrotizing granulomatous meningoencephalitis due to Balamuthia in an immunocompetent child.

Neurology·2011
Same author

Treatment of empyema by aspiration and chemotherapy.

Chinese medical journal (Peking, China : 1932)·2010
Same author

Lymphocytic vasculitis presenting as diffuse subcutaneous edema after hepatitis B virus vaccine.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008

Malignant degeneration in pleomorphic xanthoastrocytoma is rare. Increased mitosis, necrosis, and cell proliferation markers like MIB-1 may indicate a higher-grade tumor, even without prior radiation.

Area of Science:

  • Neuro-oncology
  • Surgical pathology

Background:

  • Pleomorphic xanthoastrocytoma (PXA) is a rare glial tumor.
  • Malignant transformation of PXA is infrequently documented.

Observation:

  • This report details two cases of PXA, one exhibiting malignant degeneration over 18 years without prior radiation.
  • Both anaplastic tumors showed necrosis, increased mitotic activity, and glial fibrillary acidic protein (GFAP) positivity.
  • MIB-1 labeling indices were significantly elevated in recurrent/anaplastic tumors compared to the initial low-grade tumor.

Findings:

  • Histological features like increased mitosis, necrosis, and elevated MIB-1 labeling indices (cell proliferation marker) may suggest aggressive behavior in PXA.
  • p53 protein expression was noted in one anaplastic tumor.

Related Experiment Videos

  • Cyclin D1 immunoreactivity was not significant in either anaplastic tumor.

    • Implications:

    • Histology alone may not reliably predict PXA's aggressive potential.
    • These markers could aid in identifying higher-grade PXA and guiding treatment decisions.
    • Further research is needed to understand the mechanisms of malignant transformation in PXA.