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Updated: Aug 15, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning
Published on: September 2, 2010
Neuroprotection--rationale for pharmacological modulation of Na(+)-channels
1Pfizer Central Research, Sandwich, United Kingdom.
Abstract:
The primary factor detrimental to neurons in neurological disorders associated with deficient oxygen supply or mitochondrial dysfunction is insufficient ATP production relative to their requirement. As a large part of the energy consumed by brain cells is used for maintenance of the Na+ gradient across the cellular membrane, reduction of energy demand by down-modulation of voltage-gated Na(+)-channels is a rational strategy for neuroprotection. In addition, preservation of the inward Na+ gradient may be beneficial because it is an essential driving force for vital ion exchanges and transport mechanisms such as Ca2+ homeostasis and neurotransmitter uptake.
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