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Synthesis and antitumor activity of leinamycin derivatives: modifications of C-8 hydroxy and C-9 keto groups
Y Kanda1, T Ashizawa, Y Saitoh
1Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A series of leinamycin derivatives were synthesized and evaluated for antitumor activity. Modifications at C-8 and C-9 positions revealed a broad structure-activity relationship in vitro and some derivatives showed potent antiproliferative activity against HeLa S3 cells.