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Phthalimidomethyl as a drug pro-moiety. Probing its reactivity
J Iley1, T Calheiros, R Moreira
1Chemistry Department, Open University, Milton Keynes, U.K.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
Phthalimidomethyl derivatives 1, encompassing a wide range of leaving group abilities, are rapidly hydrolysed to the corresponding phthalamic acid via rate-determining attack at the phthalimide carbonyl group.
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