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Synthesis of some hydroxynaphthazarins and their cardioprotective effects under ischemia-reperfusion in vivo
Anufriev VPh1, V L Novikov, O B Maximov
1Pacific Institute of Bioorganic Chemistry, Russian Academy of Sciences, Vladivostok, Russia. anufriev@piboc.marine.su
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A series of hydroxynaphthazarins has been synthesized. Some of them were found in in vivo experiments to be protectors of myocardium under ischemia-reperfusion and to reduce the infarction zone by 50% without any adverse effect. All compounds exhibit a moderate or small toxicity and are active in low doses.