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Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral
S Tomasi1, M Le Roch, J Renault
1Pharmacochimie de Molécules de Synthèse et de Produits Naturels, Faculté de Pharmacie, Rennes, France.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A series of N1-monosubstituted putrescine and spermine derivatives was synthesised using a solid phase methodology. We evaluated their cytotoxicity, calmodulin antagonism and polyamine uptake inhibition, pharmacological properties shared by some antitumoral agents.