Related Experiment Videos
Synthesis and cytotoxic activity of novel 10-alkylated docetaxel analogs
K Nakayama1, H Terasawa, I Mitsui
1New Product Research Laboratories IV, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
An alkylation method of docetaxel at the C-10 position has been established by a radical coupling reaction using a 10-xanthate derivative of 7-O-TES-10-deacetylbaccatin III and appropriate alkenes. In addition the cytotoxic activity of 10-alkylated docetaxel analogs was evaluated. Among these analogs, a derivative having a methoxycarbonyl group at the end of the alkyl moiety exhibited more potent cytotoxic activity than docetaxel.