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Recognition of 2'-deoxyisoguanosine triphosphate by HIV-1 reverse transcriptase and mammalian cellular DNA
M J Lutz1, J Horlacher, S A Benner
1Department of Chemistry, ETH Zürich, Universitätstr, Switzerland. michael.lutz@pharma.novartis.com
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
HIV-1 reverse transcriptase (RT) incorporates 2'-deoxyisoguanosine triphosphate (d-isoGTP) opposite thymidine (T) in a DNA template and opposite uracil (U) in an RNA template about 10 times more efficiently than the eukaryotic DNA polymerase alpha, both in the absence and presence of dATP.
Keywords:
Non-programmatic