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Updated: Aug 9, 2026
09:40
Detection of True IgE-expressing Mouse B Lineage Cells
Published on: December 1, 2014
Selective inhibition of low affinity IgE receptor (CD23) processing
S Bailey1, B Bolognese, D R Buckle
1SmithKline Beecham Pharmaceuticals, Epsom, Surrey, UK.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A series of hydroxamic acids related to the non-selective matrix metalloproteinase inhibitor Batimastat has been prepared, some members of which are potent inhibitors of the processing of the low affinity IgE receptor (CD 23). Increased activity is obtained by appropriate substitution at the alpha-position, whilst selectivity is gained by use of a P1' benzyl group in conjunction with a C-terminal primary amide.
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