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Carbocyclic frenolicin analogues: novel anticoccidial agents
R E Armer1, C J Dutton, B R Fenner
1Pfizer Central Research, Sandwich, Kent.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
Carbocyclic analogues of the antibacterial natural product frenolicin B have been synthesised. These analogues were active against parasitic protozoa of the genus Eimeria and represent a new series of anticoccidial agents. The synthesis of simplified analogues helped to define a possible pharmacophore for frenolicin.