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Alkylation of succinates: synthesis of Ro 32-3555
1Pfizer Central Research, Groton, CT 06340, USA.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32-3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives.