Related Experiment Videos
New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells
I Ojima1, P Y Bounaud, C Takeuchi
1Department of Chemistry, State University of New York at Stony Brook 11794-3400, USA.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (< or = 99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.