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A paclitaxel analogue with a 2(3-->20)abeotaxane skeleton: synthesis and biological evaluation
J Soto1, J L Mascareñas, L Castedo
1Departamento de Química Orgánica, Facultade de Química, Universidade de Santiago de Compostela, Spain.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A paclitaxel analogue having an unusual tricyclic [9.3.1.1] hexadecane skeleton was synthesized from deaminoacyltaxine A, a 2(3-->20) abeotaxane isolated in considerable amounts from the leaves of Taxus baccata L. In preliminary studies, this compound showed a much lower cytotoxicity than paclitaxel.