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Synthesis of Dolastatin 15 mimetic peptoids
J Schmitt1, M Bernd, B Kutscher
1Institut für Organische Chemie und Biochemie Technischen Universität München, Garching, Germany.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human cancer cell lines and did not show any cytostatic properties.