Related Experiment Videos
Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists
P L Ornstein1, M B Arnold, W H Lunn
1Lilly Research Laboratories, Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
We report the synthesis and characterization of compounds that are competitive NMDA receptor antagonists. Significant increases in affinity and potency were obtained by incorporation of a heteroatom into the substructure of the tetrazole-substituted amino acid LY233053.