Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complexation of okadaic acid: a preliminary study

M Norte1, J J Fernández, M L Souto

  • 1Instituto Universitario de Bioorgánica Antonio González, Universidad de La Laguna, Tenerife, Spain. mnorte@ull.es

Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Structure-preserving Gaussian denoising of FIB-SEM volumes" [Ultramicroscopy Volume 246, 113674].

Ultramicroscopy·2024
Same author

Structure-preserving Gaussian denoising of FIB-SEM volumes.

Ultramicroscopy·2022
Same author

The role of electrochemical potentials of solid-state energy emissive harvesters.

Heliyon·2022
Same author

Optical flow driven interpolation for isotropic FIB-SEM reconstructions.

Computer methods and programs in biomedicine·2022
Same author

Gene annotation of nuclear receptor superfamily genes in the kissing bug Rhodnius prolixus and the effects of 20-hydroxyecdysone on lipid metabolism.

Insect molecular biology·2021
Same author

Delocalization and heat transport in multidimensional trapped ion systems.

Physical review. E·2019

Okadaic acid (OA) complexation with metal ions, particularly K+, was studied. Potassium

Area of Science:

  • Biochemistry
  • Pharmacology
  • Coordination Chemistry

Background:

  • Okadaic acid (OA) is a potent marine toxin with significant biological activities.
  • Understanding OA's interactions with metal ions is crucial for its pharmacological applications and toxicological assessment.

Purpose of the Study:

  • To investigate the complexation of okadaic acid (OA) with various metal ions.
  • To determine the influence of metal ion complexation on OA's pharmacological activity.

Main Methods:

  • Complexation reactions between OA and Li+, Na+, K+, Ca2+, and Mg2+ were performed.
  • Characterization of the resulting complexes was conducted.
  • Pharmacological trials were carried out on the OA-metal ion complexes.

Related Experiment Videos

Main Results:

  • Complexation of OA with K+ yielded a product identical to a naturally occurring complex (OAC).
  • Pharmacological testing revealed that K+ significantly modulates the activity of OA.
  • Differential effects of other studied metal ions (Li+, Na+, Ca2+, Mg2+) on OA's activity were observed.

Conclusions:

  • Potassium ions play a critical role in the pharmacological profile of okadaic acid.
  • The specific interaction between K+ and OA influences its biological effects.
  • Further research into OA-metal ion interactions can lead to novel therapeutic or toxicological insights.