Related Experiment Videos
Polymer supported bases in solution-phase synthesis. 2. A convenient method for N-alkylation reactions of weakly
1Pharmaceuticals Discovery, Berlex Biosciences, Richmond, CA 94804, USA.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A convenient solution-phase method for N-alkylation reactions of weakly acidic heterocycles employing polymer supported super base PBEMP is described. By using this method, multiple-step and chemoselective N-alkylation sequences can be carried out in a one-pot process.