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Recognition of a non-standard base pair by thermostable DNA polymerases
M J Lutz1, J Horlacher, S A Benner
1Department of Chemistry, ETH Zürich, Switzerland. michael.lutz@pharma.novartis.com
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
Examination of several commercially available thermostable DNA polymerases identifies 9 degrees N DNA polymerase as single enzyme that could incorporate two components of an expanded genetic alphabet, 2,4-diaminopyrimidine and xanthosine as deoxynucleoside triphosphate opposite their cognate base in a DNA template.
Keywords:
Non-programmatic