Related Experiment Videos
A novel super-potent neurokinin A receptor antagonist containing dehydroalanine
A Lombardi1, B D'Agostino, F Nastri
1Centro Interuniveristario di Ricerca su Peptidi Bioattivi, Università di Napoli Federico II, Italy.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity. Its pharmacological properties as a neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and were compared to those of Neuronorm and MEN10627.