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Synthesis and anti-inflammatory activity of chalcone derivatives
F Herencia1, M L Ferrándiz, A Ubeda
1Departamento de Farmacología, Universidad de Valencia, Spain.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
Chalcones and their derivatives were synthesized and evaluated for their anti-inflammatory activity. In vitro, chalcones 2, 4, 8, 10 and 13 inhibited degranulation and 5-lipoxygenase in human neutrophils, whereas 11 behaved as scavenger of superoxide. Only four compounds (4-7) inhibited cyclo-oxygenase-2 activity. The majority of these samples showed anti-inflammatory effects in the mouse air pouch model.