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Synthesis of tools for target identification of the anti-apoptotic compound CGP 3466; Part I
K Zimmermann1, S Roggo, E Kragten
1Novartis Pharma Inc., Basel/Switzerland. Kaspar.Zimmermann@pharma.novartis.com
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
Immobilized compounds for BIAcore studies and affinity precipitation as well as a fluorescent-labeled compound were prepared in order to identify the molecular target of the anti-apoptotic, neurorescuing compound CGP 3466 (N-methyl-N-propargyl-10-aminomethyl-dibenzo[b,f]oxepin).