Related Experiment Videos
Design and synthesis of bio-isosteres of thymidine triphosphate
A O Goldring1, J Balzarini, I H Gilbert
1Welsh School of Pharmacy, University of Wales Cardiff, U.K.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
This paper describes the design and synthesis of potential isosteres of triphosphates which should show enhanced metabolic stability and lipophilicity compared to triphosphates. The triphosphate isosteres were then linked to nucleosides and evaluated for their inhibitory activity against HIV infection.