1,2-disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors
N J Harmat1, C Di Bugno, M Criscuoli
1Menarini Ricerche S.p.A. Laboratori di Firenze, Italy.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted in a potent and selective thrombin inhibitor.
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