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Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives
1Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill 27599-7360, USA.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
Eleven betulin derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Compound 4 was found to be the most active with EC50 and TI values of 0.00066 microM and 21,515, respectively.