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Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists
B Cimetière1, T Dubuffet, O Muller
1Institut de Recherches Servier, Centre de Recherches de Croissy, Croissy-sur-Seine, France.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
New polysubstituted tetrahydronaphthalene derivatives were prepared as thromboxane receptor (TP-receptor) antagonists. Within this series of compounds S 18886 has been identified as an orally active, highly potent antagonist with a very long duration of action in different species.