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Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents
D Subrahmanyam1, B Renuka, C V Rao
1Natural Products Division, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
Several D-ring modified analogues of podophyllotoxin were prepared viz semi-synthesis starting from naturally occurring podophyllotoxin and determined their in vitro anti-cancer activity. Most of the analogues have shown good activity towards human cancer cell lines.