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A 'sticky' interhemispheric switch in bipolar disorder?

J D Pettigrew1, S M Miller

  • 1Vision, Touch and Hearing Research Centre, University of Queensland, St Lucia, Brisbane, Australia. j.pettigrew@vthrc.uq.edu.au

Proceedings. Biological Sciences
|January 1, 1999
PubMed
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Bipolar disorder may stem from genetic factors causing slow brain hemisphere switching. This "sticky" switching may explain manic or depressive states, offering a potential biological marker for the condition.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Bipolar disorder pathophysiology remains unclear despite its strong heritability.
  • Complex genetics, including incomplete monozygotic twin concordance and identified loci, complicate understanding.
  • Existing research has not fully elucidated the underlying mechanisms of bipolar disorder.

Purpose of the Study:

  • To propose and investigate the 'sticky' interhemispheric switching hypothesis for bipolar disorder.
  • To explore the relationship between interhemispheric switching speed and bipolar disorder.
  • To identify potential trait-dependent biological markers for bipolar disorder.

Main Methods:

  • Assessed the rate of perceptual alternation in binocular rivalry in euthymic bipolar disorder patients and healthy controls.

Related Experiment Videos

  • Utilized binocular rivalry as a measure of interhemispheric switching rate.
  • Analyzed the robustness and test-retest reliability of the interhemispheric switch rate.

    • Main Results:

    • Euthymic subjects with bipolar disorder exhibited significantly slower perceptual alternation rates (median = 0.27 Hz) compared to normal controls (median = 0.60 Hz, p < 0.0005).
    • Binocular rivalry alternation rate demonstrated high individual robustness (test-retest correlation > 0.8).
    • Slowed interhemispheric switching was observed in individuals with bipolar disorder.

    Conclusions:

    • The 'sticky' interhemispheric switching hypothesis offers a potential explanation for bipolar disorder's pathophysiology.
    • Interhemispheric switch rate, measured via binocular rivalry, may serve as a stable, trait-dependent biological marker for bipolar disorder.
    • This finding could pave the way for novel diagnostic or therapeutic strategies targeting brain connectivity in bipolar disorder.