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Arrhythmogenic right ventricular dysplasia/cardiomyopathy: review for the clinician
K Ananthasubramaniam1, F Khaja
1Henry Ford Hospital, Heart and Vascular Institute, Detroit, MI 48202, USA.
Insights
Arrhythmogenic right ventricular dysplasia (ARVD) is an increasingly recognized cause of sudden cardiac death in young individuals. This review covers ARVD
Area of Science:
- Cardiology
- Genetics
- Pathology
Background:
- Sudden cardiac death in young people is often linked to hypertrophic obstructive cardiomyopathy.
- Rarer causes, like arrhythmogenic right ventricular dysplasia (ARVD), are gaining recognition.
- Advances in understanding ARVD necessitate a comprehensive review.
Purpose of the Study:
- To review the etiopathogenesis of ARVD.
- To outline the clinical manifestations and diagnostic approaches for ARVD.
- To discuss current and emerging treatment modalities for ARVD.
Main Methods:
- Literature review of recent advances in ARVD research.
- Synthesis of information on genetic inheritance and disease mechanisms.
- Compilation of diagnostic criteria and therapeutic strategies.
Main Results:
- ARVD is a significant cause of sudden cardiac death in younger populations.
- Genetic factors play a crucial role in the inheritance and development of ARVD.
- Early diagnosis and appropriate management are key to improving outcomes.
Conclusions:
- ARVD is an important consideration in young sudden cardiac death cases.
- Continued research into ARVD genetics and pathophysiology is vital.
- Multidisciplinary management improves patient prognosis for this right ventricular cardiomyopathy.
Abstract:
Although hypertrophic obstructive cardiomyopathy remains the most common cause of sudden cardiac death in young people, rarer causes, such as arrhythmogenic right ventricular dysplasia (ARVD), are now being increasingly recognized to lead to sudden cardiac death in the younger population. Recent advances in the understanding of the genetic inheritance, etiopathogenesis, diagnosis, and treatment options of ARVD have prompted a lot of research in this form of right ventricular cardiomyopathy. The purpose of this report is to review the etiopathogenesis, clinical manifestations, diagnosis and treatment modalities for ARVD, and recent advances in the understanding of this disease entity.