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Updated: Aug 12, 2026
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Life threatening diarrhoea ultimately cured by surgery
U Sjöqvist1, J Permert, R Löfberg
1Department of Gastroenterology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
European Journal of Gastroenterology & Hepatology
|January 1, 1999
Summary
A pancreatic neuroendocrine tumor producing vasoactive intestinal polypeptide (VIP) caused severe dehydration. Surgical removal of the VIP-producing tumor led to immediate recovery, highlighting VIP
Area of Science:
- Endocrinology
- Oncology
- Gastroenterology
Background:
- Neuroendocrine gastrointestinal tumors can present with vague symptoms.
- Vasoactive intestinal polypeptide (VIP) is a peptide hormone implicated in various physiological processes.
Observation:
- A previously healthy 30-year-old woman developed life-threatening dehydration.
- Symptoms were linked to a diagnosed vasoactive intestinal polypeptide (VIP)-producing pancreatic tumor.
- Elevated serum concentrations of VIP and pancreastatin were noted.
Findings:
- Surgical resection of the VIP-producing tumor resulted in immediate patient recovery.
- Post-operative analysis revealed elevated levels of growth factors: IGF-I, EGF, and TGF-alpha.
- The study discusses the correlation between peptide level alterations and patient symptomatology.
Implications:
- Highlights the critical role of VIP in severe dehydration associated with pancreatic neuroendocrine tumors.
- Demonstrates the efficacy of surgical intervention for VIP-producing tumors.
- Suggests potential involvement of growth factors in the post-operative recovery or tumor biology.
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