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Functionalization of a viscosity-sensitive fluorophore for probing of biological systems
A Petric1, A F Jacobson, J R Barrio
1Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia. andrej.petric@uni-lj.si
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Functionalization of a viscosity-sensitive visible wavelength fluorophore 2-(1,1-dicyanopropenyl-2)-6-dimethylaminonaphthalene (DDNP), with the intent to incorporate its favorable optical properties into a probe for structural and functional imaging by fluorescence microscopy, is described. Spiperone, a highly potent ligand for the dopamine D2 receptors, was conjugated via an ethylpiperazine moiety to the fluorophore giving fluorescent probes that can be excited in the UV and Vis range.