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Evaluation of phosphorus-containing inhibitors of gamma-glutamyl hydrolase
C E Rodriguez1, H M Holmes, K L Mlodnosky
1Department of Chemistry & Biochemistry, San Francisco State University, CA 94132, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Several putative, phosphorus-containing inhibitors of gamma-glutamyl hydrolase were synthesized and evaluated for inhibitory activity. The phosphonamidoic acids were shown to be weak competitive inhibitors while both a phosphoramidate diester and a phosphonamidate ester were shown to be potent time-dependent inactivators, presumably through irreversible phosphorylation of an active site nucleophile.