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A potent dipeptide inhibitor of dipeptidyl peptidase IV
M Yamada1, C Okagaki, T Higashijima
1Lead Generation Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A series of novel potent inhibitors of dipeptidyl peptidase IV (DPP-IV) has been developed. A brief structure-activity relationship of the inhibitors was investigated. The dipeptide TSL-225, tryptophyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, was identified with the critical structure for the inhibitory activity.