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Asymmetric synthesis and anti-HIV activity of L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine
P Wang1, R F Schinazi, C K Chu
1Center for Drug Discovery, University of Georgia College of Pharmacy, Athenes, GA 30602, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Asymmetric synthesis of L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine and its analogs were accomplished and their anti-HIV activities were evaluated. It was found that L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine exhibited moderately potent anti-HIV (EC50 = 2.4 microM) activity in human PBM cells without cytotoxicity up to 100 microM.