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Synthesis and biological activity of lactones en route to Altohyrtin A
S A Hermitage1, A Murphy, S M Roberts
1Department of Chemistry, Robert Robinson Laboratories, University of Liverpool, England.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Lactones 2 and 7 were synthesised and tested against six human tumour cell lines (Pancreas-a, BXPC-3), (Thyroid ca, KAT-4), (Thyroid ca, SW1736), (Lung-NSC, NCI-H460), (Pharynx-sq, FADU) and (Prostate, DU-145). Lactone 7 proved inactive, but lactone 2 displayed some activity against four of the six cell lines examined. Both lactones were converted into an intermediate 5 en route to Altohyrtin A.