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Adenosine deaminase inhibitors. Synthesis and biological evaluation of aralkyladenines (ARADS)
M A Curtis1, V Varkhedkar, P V Pragnacharyulu
1Department of Biomedical Sciences, University of Rhode Island, Kingston 02881-0809, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Several 9-aralkyladenines have been prepared and their ADA inhibitory activity was determined. A minimum of two carbon atoms separating the aromatic ring from the adenine-bearing carbon (C3') was found essential for potent activity.