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Inhibitors of the bacterial cell wall biosynthesis enzyme MurD
L D Gegnas1, S T Waddell, R M Chabin
1Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.