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Solution and solid phase combinatorial synthesis of peptidomimetic library containing diversified alpha-methylated
1Biotech Research Institute, LG Chemical Ltd./Research Park, Science Town, Taejon, Korea.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A combinatorial peptidomimetic library containing diversified alpha-methylated amino acids was generated by the Ugi four component condensation (4cc) reaction from acids, amines, isocyanides and ketones in both solution and solid phase synthetic procedures. This one-pot methodology overall gave fair to good yields, which compare well with multi-step syntheses.