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Published on: April 6, 2017
Unusual synthesis of new glycine antagonists via sequential aldol condensation-lactonization-elimination reaction
S A Giacobbe1, D Baraldi, R Di Fabio
1GlaxoWellcome S.p.A., Medicines Research Center, Verona, Italy.
Abstract:
Compounds 2 and 3 were designed in order to probe the North-East region of the strichnine-insensitive glycine binding site of the NMDA receptor. The two products were obtained readily by a tandem aldol condensation-lactonization-elimination step which affords the desired E isomer with complete regioselection.
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