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Neuronorm is a potent and water soluble neurokinin A receptor antagonist
A Lombardi1, B D'Agostino, A Filippelli
1Centro Interuniveristario di Ricerca su Peptidi Bioattivi, Università di Napoli Federico II, Italy.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
We report here the synthesis and preliminary pharmacological characterization of a novel water soluble Neurokinin A receptor antagonist named Neuronorm. The synthesis was achieved in high yield by a combination of classical peptide synthesis methodologies, in both solution and solid phase. The pharmacological properties as neurokinin A receptor antagonist were assessed in in vitro experiments on rat vas deferens and guinea pig trachea, and were compared to those of MEN10627.