Related Experiment Videos
Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents
D G Batt1, J J Petraitis, S R Sherk
1DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0500, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.