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Synthesis of a high-mannose-type glycopeptide analog containing a glucose-asparagine linkage
I L Deras1, K Takegawa, A Kondo
1Biology Department, Johns Hopkins University, Baltimore, MD 21218, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
The title compound was prepared by enzymatic transfer of oligosaccharide to a synthetic pentapeptide containing the Glc-Asn linkage. The compound was not hydrolyzed by glycoamidases from plant and bacterial sources, but it inhibited both enzymes in the micromolar range. Its activity is compared to other potential inhibitors.