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Development of new chromanol antagonists of leukotriene D4

R J Chambers¹, G W Antognoli, J B Cheng

¹Central Research Division, Pfizer Inc., Groton, CT 06340, USA.

Bioorganic & Medicinal Chemistry Letters

|January 5, 1999

Abstract:

By addressing the issues of potency and metabolism in 3, a new series of LTD4 antagonists represented by (+)-26 was developed which is equipotent to clinical LTD4 antagonists Zafirlukast (1) and Pranlukast (2).

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