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Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring

S S Jew¹, M G Kim, H J Kim

¹College of Pharmacy, Seoul National University, Korea.

Bioorganic & Medicinal Chemistry Letters

|January 5, 1999

Abstract:

A series of C(7) and C(20)-substituted camptothecin derivatives (12-14, 16-18) are prepared. Their syntheses and in vitro cytotoxicities are reported.

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