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Serine derived NK1 antagonists. 2: A pharmacophore model for arylsulfonamide binding
J M Elliott1, H Broughton, M A Cascieri
1Merck Sharp and Dohme Research Laboratories, Neuroscience Research Center, Harlow, Essex, U.K.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Modifications to the spirocyclic aryl sulfonamide portion of serine derived NK1 antagonists allow a partial pharmacophore model to be developed.